Derek Dykxhoorn, Ph.D.
- Associate Professor, Microbiology and Immunology
- Co-Director, Center for Molecular Genetics, John P. Hussman Institute for Human Genomics
- Research Associate Professor, Dr. John T. Macdonald Foundation Department of Human Genetics
- miR-200 enhances mouse breast cancer cell colonization to form distant metastases.
- Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
- Identification of host proteins required for HIV infection through a functional genomic screen.
- Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.
- siRNA-directed inhibition of HIV-1 infection.
- List of Publications
Derek M. Dykxhoorn, Ph.D., is an Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics, and the Department of Microbiology and Immunology. He is also Co-Director of the Center for Human Molecular Genetics at the John P. Hussman Institute for Human Genomics. He is a molecular biologist interested in the mechanisms that regulate pathogenesis. His current research focuses on the impact that genetic and epigenetic variations have on the transmission, infection and replication of HIV-1. In particular, his research has focused on the application of functional genomic approaches (RNA interference) to understand disease processes, including the use of large-scale, full genome screening platforms for the identification of host factors, HIV-dependency factors (HDFs), required for HIV infection and replication and the development of novel siRNA delivery approaches that can be used for therapeutic intervention for HIV infected individuals or formulated into a microbicide to prevent viral transmission across mucosal surfaces.