Xiang-Xi "Mike" Xu, Ph.D.
- Professor of Cell Biology
Ovarian cancer Biology and early embryogenesis:
1. Pre-malignant lesions in ovarian carcinogenesis
2. Menopause and ovarian cancer risk
3. Dab2 in endocytosis and signalings
4. Primitive endoderm formation in early mouse embryogenesis
5. Nuclear envelope changes and defects in stem cell differentiation and cancer
- Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.
- Development of a mouse model of menopausal ovarian cancer.
- The primitive endoderm segregates from the epiblast in ß1 integrin-deficient early mouse embryos.
- Hormonal induction and roles of Disabled-2 in lactation and involution.
- Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.
- Xu publications from the University of Miami
Xiang-Xi Mike Xu obtained his B.S. in Chemistry from ZhongShan University (China) in 1984, Ph.D. in Biochemistry from Emory University (Atlanta, GA) in 1989. He did his postdoctoral training at Columbia University (New York, NY) (1989-1992); and St. Jude Children's Research Hospital (Memphis, TN) (1992-1995). Dr. Xu started as an Assistant Professor at Department of Biochemistry and Winship Cancer Institute at Emory University (1996-2000), was an Associate Member at Fox Chase Cancer Center (Philadelphia, PA) (2000-2007), and started as a Professor at the University of Miami in 2008.
Dr. X. Mike Xu uses mouse modles to study ovarian cancer biology and etiology, and to investigate the formation of primitive endoderm in early blastocysts and embryos.