Guy J. Leclerc, Ph.D.
- Fax: 305-243-2691
- Assistant Professor
Uniformed Services University of Health Sciences
University of South Carolina
University of Montreal
University of Montreal
1982 Diplome Etudes Collegiales
- Leclerc GM, Leclerc GJ, Fu G, Barredo JC. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. Journal of Molecular Signaling 2010; 5: 15.
- Leclerc GJ, Sanderson C, Hunger S, Devida M, Barredo JC. Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia. Leuk Res. 2010; Epub ahead of print.
- Leclerc GJ, Mou C, Leclerc GM, Mian AM, Barredo JC. Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 2010; 24:552-562.
- Sengupta TK, Leclerc GM, Kinser TH, Leclerc GJ, Singh I, Barredo JC. Cytotoxic Effect of 5-Aminoimidazole-4-Carboxamide-1-ß-4-Ribofuranoside (AICAR) on Childhood Acute Lymphoblastic Leukemia (ALL) Cells: Implication for Targeted Therapy. Molecular Cancer. 2007; 6:46.
- Leclerc GJ, Kinser TH, Bunni M, Altman-Hamamdzic S, York T, Barredo JC. Characterization of mutations in folylpoly-gamma-glutamate synthetase gene that lead to resistance to polyglutamylation. Leukemia Research. 2006; 3:293-299.
- Leclerc GJ, Leclerc GM, Kinser TH, Barredo JC. Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells. BMC Cancer. 2006; 6:132.
- Leclerc GM, Leclerc GJ, Frawley LS, Boockfor FR. Cloning and expression of the Ca2+-binding transcriptional repressor DREAM in the pituitary. General and Comparative Endocrinology. 2002; 129:45-55.
- Leclerc GJ, Leclerc GM, Barredo JC. Real-Time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cells. Cancer Cell International. 2002; 2:1-4.
- Leclerc GJ, Barredo JC. Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues. Clin. Cancer Res. 2001; 7:942-51.
- Leclerc GM, Han K, Leclerc GJ, Ely B. Characterization of a highly repetitive sequence conserved among the North American Morone species. Marine Biotechnology. 1999; 1:122-130.
- Leclerc GJ, Tartera C, Weinstein D, Metcalf ES. Characterization of outer membrane proteins of Salmonella typhi: construction and analysis of defined flagella-negative mutants. Infect. Immun. 1999.
- Leclerc GJ, Wang SP, Ely B. A New Class of Caulobacter crescentus flagellar genes. J. Bacteriol. 1998; 180:5010-5019.
- Leclerc GJ, Noel G, Drapeau GR. Molecular Cloning, Nucleotide Sequence, and Expression of shl, a New Gene in the 2- Minute Region of the Genetic Map of Escherichia coli. J. Bacteriol. 1990; 172:4696-4700.