Drug abuse and AIDS risk and progression. HIV-1 gene expression in AIDS chronic neurologic disease and in Alzheimer's disease. Gene expression in NeuroAIDS. Bioinformatics, development of databases, and network analyses of Gene Expression in the human disease brain. Development of Ribozymes, siRNA, and vectors specific for genes in Drug Abuse and Neuropsychiatric disease.  Application of nanotechnology to Biology and Medicine. Prevention of spread of AIDS: transmission model and inactivation of HIV-1. Nitric Oxide, Cytokines and other factors in NeuroAIDS: modulators of progression and of HIV-1 replication and evolution in the central and peripheral nervous systems. Lab ora tory measures of NeuroAIDS, Alzheimer's disease, Multiple Sclerosis, Schizophrenia.

 

 

EDUCATION:      

 

1955 - 1959               High School of Music and Art, NY, NY

 

1959 - l963                BA, Harvard College , Cambridge, MA (Biochemistry)

 

1963 - 1964               New York University Medical Center, NY, NY (Biochemistry)

 

1964 - 1969               PhD, Princeton University , Princeton, NJ (Biochemistry)

 

1972-1973                 Fellowship, University of Wisconsin , Madison, WI (Molecular Virology)

 

1973- 1975                Staff Fellow, NIH (NICHD), Bethesda, MD (Molecular Biology)

 

 

 

 

PRIOR POSITIONS HELD:

 

September 1990-November 1992        University of Miami Medical School

 

Associate Professor in Research

 

Departments of Psychiatry, Neurology, Pathology

 

Comprehensive Drug Research Center

 

 

September 1988-August 1990            MOUNT SINAI MEDICAL CENTER

 

                                                                                Chief of Molecular Viral Pathology, Pearlman Research Center

 

 

October 1988-August 1990 University of Miami Medical School

 

                                                                                Adjunct Associate Professor

 

                                                                                Departments of Neurology and Pathology

 

 

July 1986-August 1988                        UCLA SCHOOL OF MEDICINE AND

 

                    HARBOR-UCLA MEDICAL CENTER

 

                    Adjunct Associate Professor

 

                    Departments of Neurology and Pediatrics

 

February 1981-August 1988               VETERANS ADMINISTRATION

 

                    WEST LOS ANGELES MEDICAL CENTER

 

                    WADSWORTH DIVISION

 

                    Los Angeles, California 90073

 

                    Neurology Service, 127A

 

                    Chief, Molecular Virology and Immunology

 

                    GS-13

 

 

November 1983-August 1988             UCLA JONSSON COMPREHENSIVE CANCER CENTER

 

                    Westwood, California 90024

 

                    Associate Member

 

 

January 1979-June 1986                      UCLA SCHOOL OF MEDICINE AND HARBOR-UCLA

 

                                                                                MEDICAL CENTER

 

                                                                                Adjunct Assistant Professor

 

                                                                                Departments of Pediatrics and Neurology

 

 

March 1984-May 1984                         UCLA

 

                                                                                Acting Assistant Professor

 

                                                                                Departments of Chemistry, Molecular Biology, and Biochemistry

 

 

February 1982-October 1983              VETERANS ADMINISTRATION

 

                    WEST LOS ANGELES MEDICAL CENTER

 

                    WADSWORTH DIVISION

 

                    Los Angeles, California 90073

 

                    Department of Neurology

 

                    Co-Director, National Neurological Research Bank

 

 

February 1977-July 1978                                     REDKEN LABORATORIES, INC.

 

                                                                             

14721 Califa Street

 

                                                                              Van Nuys, California 91411

 

                                                                              Manager of the R & D Biochemistry Lab ora tory

 

 

July 1975-January 1977                                       UCLA SCHOOL OF MEDICINE

 

                                                                                Westwood, California 90024

 

                                                                                Postdoct ora l Fellow, Departments of Microbiology/Immunology,

 

                                                                                and Pathology

 

 

July 1973-June 1975                                             NATIONAL INSTITUTES OF HEALTH

 

                                                                              National Institute for Child Health

 

                                                                              and Human Development

 

                                                                              Bethesda, Maryland 20205

 

                                                                              Staff Fellow

 

 

March 1973-June 1973                                         LITTON BIONETICS, INC.

 

                                                                              FREDERICK CANCER RESEARCH CENTER

 

                                                                              (National Cancer Institute)

 

                                                                              Ft. Detrick

 

                                                                              Frederick, Maryland 21701

 

                                                                              Senior Scientist, Advanced Systems Lab ora tory

 

 

March 1972-February 1973                                 UNIVERSITY OF WISCONSIN

 

                                                                              Madison, Wisconsin 53706

 

                                                                              Postdoct ora l Fellow, Biophysics Lab ora tory

 

 

 

 

 

September 1971-February 1972                          CORNELL UNIVERSITY

 

                                                                                School of Engineering

 

                                                                                Ithaca, New York 14853

 

                                                                                Post-doct ora l Fellow, Department of Applied Physics

 

 

September 1969-August 1971                            CORNELL UNIVERSITY

 

                                                                              Center for Radiophysics and Space Research (NASA)

 

                                                                              Ithaca, New York 14853

 

                                                                              Research Associate, Lab ora tory for Planetary Studies