UHealth - University of Miami Health System

John L. Bixby

General Information

John L. Bixby


  • .(JavaScript must be enabled to view this email address)


  • English


  • Professor


Clinical Interests

Cell signaling, neuroscience, development

Research Interests

Axon growth and guidance, synapse formation, neuronal regeneration, tyrosine phosphosphatases

1: Stepanek L, Stoker AW, Stoeckli E, Bixby JL.
Free Full Text Receptor tyrosine phosphatases guide vertebrate motor axons during development.
J Neurosci. 2005 Apr 13;25(15):3813-23.
PMID: 15829633 [PubMed - indexed for MEDLINE]

2: Dimitropoulou A, Bixby JL.
Abstract Motor neurite outgrowth is selectively inhibited by cell surface MuSK and agrin.
Mol Cell Neurosci. 2005 Feb;28(2):292-302.
PMID: 15691710 [PubMed - indexed for MEDLINE]

3: Chen B, Bixby JL.
Free Full Text A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth.
J Neurosci. 2005 Jan 26;25(4):880-8.
PMID: 15673668 [PubMed - indexed for MEDLINE]

4: Chen B, Bixby JL.
Abstract Neuronal pentraxin with chromo domain (NPCD) is a novel class of protein expressed in multiple neuronal domains.
J Comp Neurol. 2005 Jan 24;481(4):391-402.
PMID: 15593341 [PubMed - indexed for MEDLINE]

5: Ernsberger U, Esposito L, Partimo S, Huber K, Franke A, Bixby JL, Kalcheim C, Unsicker K.
Abstract Expression of neuronal markers suggests heterogeneity of chick sympathoadrenal cells prior to invasion of the adrenal anlagen.
Cell Tissue Res. 2005 Jan;319(1):1-13. Epub 2004 Nov 25.
PMID: 15565470 [PubMed - indexed for MEDLINE]

6: Baerwald-de la Torre K, Winzen U, Halfter W, Bixby JL.
Abstract Glycosaminoglycan-dependent and -independent inhibition of neurite outgrowth by agrin.
J Neurochem. 2004 Jul;90(1):50-61.
PMID: 15198666 [PubMed - indexed for MEDLINE]

7: Beltran PJ, Bixby JL, Masters BA.
Abstract Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.
J Comp Neurol. 2003 Feb 17;456(4):384-95.
PMID: 12532410 [PubMed - indexed for MEDLINE]

8: Chen B, Hammonds-Odie L, Perron J, Masters BA, Bixby JL.
Abstract SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons.
Dev Biol. 2002 Dec 15;252(2):170-87.
PMID: 12482708 [PubMed - indexed for MEDLINE]

9: Beltran PJ, Bixby JL.
Abstract Receptor protein tyrosine phosphatases as mediators of cellular adhesion.
Front Biosci. 2003 Jan 1;8:d87-99. Review.
PMID: 12456340 [PubMed - indexed for MEDLINE]

10: Bixby JL, Baerwald-De la Torre K, Wang C, Rathjen FG, Ruegg MA.
Abstract A neuronal inhibitory domain in the N-terminal half of agrin.
J Neurobiol. 2002 Feb 5;50(2):164-79.
PMID: 11793362 [PubMed - indexed for MEDLINE]

11: Patzke H, Reissmann E, Stanke M, Bixby JL, Ernsberger U.
Abstract BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development.
Mech Dev. 2001 Oct;108(1-2):149-59.
PMID: 11578868 [PubMed - indexed for MEDLINE]

12: Bixby JL.
Abstract Ligands and signaling through receptor-type tyrosine phosphatases.
IUBMB Life. 2001 Mar;51(3):157-63. Review.
PMID: 11547917 [PubMed - indexed for MEDLINE]

13: Stepanek L, Sun QL, Wang J, Wang C, Bixby JL.
Free Full Text CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro.
J Cell Biol. 2001 Aug 20;154(4):867-78.
PMID: 11514594 [PubMed - indexed for MEDLINE]

14: Sun QL, Wang J, Bookman RJ, Bixby JL.
Abstract Growth cone steering by receptor tyrosine phosphatase delta defines a distinct class of guidance cue.
Mol Cell Neurosci. 2000 Nov;16(5):686-95.
PMID: 11083928 [PubMed - indexed for MEDLINE]

15: Bixby JL.
Abstract Receptor tyrosine phosphatases in axon growth and guidance.
Neuroreport. 2000 Jul 14;11(10):R5-10. Review.
PMID: 10923644 [PubMed - indexed for MEDLINE]

16: Martins-Green M, Bixby JL, Yamamoto T, Graf T, Sudol M.
Abstract Tissue specific expression of Yrk kinase: implications for differentiation and inflammation.
Int J Biochem Cell Biol. 2000 Mar;32(3):351-64.
PMID: 10716632 [PubMed - indexed for MEDLINE]

17: Dimitropoulou A, Bixby JL.
Abstract Regulation of retinal neurite growth by alterations in MAPK/ERK kinase (MEK) activity.
Brain Res. 2000 Mar 6;858(1):205-14.
PMID: 10700616 [PubMed - indexed for MEDLINE]

18: Wang J, Bixby JL.
Abstract Receptor tyrosine phosphatase-delta is a homophilic, neurite-promoting cell adhesion molecular for CNS neurons.
Mol Cell Neurosci. 1999 Oct-Nov;14(4-5):370-84.
PMID: 10588391 [PubMed - indexed for MEDLINE]

19: Perron JC, Bixby JL.
Abstract Tetraspanins expressed in the embryonic chick nervous system.
FEBS Lett. 1999 Nov 12;461(1-2):86-90.
PMID: 10561501 [PubMed - indexed for MEDLINE]

20: Ledig MM, Haj F, Bixby JL, Stoker AW, Mueller BK.
Free Full Text The receptor tyrosine phosphatase CRYPalpha promotes intraretinal axon growth.
J Cell Biol. 1999 Oct 18;147(2):375-88.
PMID: 10525542 [PubMed - indexed for MEDLINE]

21: Perron JC, Bixby JL.
Abstract Distinct neurite outgrowth signaling pathways converge on ERK activation.
Mol Cell Neurosci. 1999 May;13(5):362-78.
PMID: 10356298 [PubMed - indexed for MEDLINE]

22: Ledig MM, McKinnell IW, Mrsic-Flogel T, Wang J, Alvares C, Mason I, Bixby JL, Mueller BK, Stoker AW.
Abstract Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick.
J Neurobiol. 1999 Apr;39(1):81-96.
PMID: 10213455 [PubMed - indexed for MEDLINE]

23: Lom B, Hopker V, McFarlane S, Bixby JL, Holt CE.
Abstract Fibroblast growth factor receptor signaling in Xenopus retinal axon extension.
J Neurobiol. 1998 Dec;37(4):633-41.
PMID: 9858264 [PubMed - indexed for MEDLINE]

24: Plunkett JA, Baccus SA, Bixby JL.
Free Full Text Differential regulation of synaptic vesicle protein genes by target and synaptic activity.
J Neurosci. 1998 Aug 1;18(15):5832-8.
PMID: 9671670 [PubMed - indexed for MEDLINE]

25: Campagna JA, Ruegg MA, Bixby JL.
Abstract Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro.
Eur J Neurosci. 1997 Nov;9(11):2269-83.
PMID: 9464922 [PubMed - indexed for MEDLINE]

26: Ruegg MA, Bixby JL.
Abstract Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction.
Trends Neurosci. 1998 Jan;21(1):22-7. Review.
PMID: 9464682 [PubMed - indexed for MEDLINE]

27: Lou XJ, Bixby JL.
Abstract Extracellular-matrix molecules expressed by innervatable muscle.
Dev Neurosci. 1997;19(4):357-67.
PMID: 9215882 [PubMed - indexed for MEDLINE]

28: Campagna JA, Prevette D, Oppenheim RW, Bixby JL.
Abstract Target contact regulates expression of synaptotagmin genes in spinal motor neurons in vivo.
Mol Cell Neurosci. 1997;8(6):377-88.
PMID: 9143556 [PubMed - indexed for MEDLINE]

29: Bodden K, Bixby JL.
Abstract CRYP-2: a receptor-type tyrosine phosphatase selectively expressed by developing vertebrate neurons.
J Neurobiol. 1996 Nov;31(3):309-24.
PMID: 8910789 [PubMed - indexed for MEDLINE]

30: Bixby JL, Bookman RJ.
Abstract Intracellular mechanisms of axon growth induction by CAMs and integrins: some unresolved issues.
Perspect Dev Neurobiol. 1996;4(2-3):147-56. Review.
PMID: 9168197 [PubMed - indexed for MEDLINE]

31: Campagna JA, Ruegg MA, Bixby JL.
Abstract Agrin is a differentiation-inducing "stop signal" for motoneurons in vitro.
Neuron. 1995 Dec;15(6):1365-74.
PMID: 8845159 [PubMed - indexed for MEDLINE]

32: Lou XJ, Bixby JL.
Abstract Patterns of presynaptic gene expression define two stages of synaptic differentiation.
Mol Cell Neurosci. 1995 Jun;6(3):252-62.
PMID: 7496630 [PubMed - indexed for MEDLINE]

33: Bixby JL.
Abstract Collagen synthesis inhibition reduces clustering of heparan sulfate proteoglycan and acetylcholine receptors but not agrin or p65, at neuromuscular contacts in vitro.
J Neurobiol. 1995 Feb;26(2):262-72.
PMID: 7707046 [PubMed - indexed for MEDLINE]

34: Bixby JL, Grunwald GB, Bookman RJ.
Free Full Text Ca2+ influx and neurite growth in response to purified N-cadherin and laminin.
J Cell Biol. 1994 Dec;127(5):1461-75.
PMID: 7962102 [PubMed - indexed for MEDLINE]

35: Kljavin IJ, Lagenaur C, Bixby JL, Reh TA.
Abstract Cell adhesion molecules regulating neurite growth from amacrine and rod photoreceptor cells.
J Neurosci. 1994 Aug;14(8):5035-49. Erratum in: J Neurosci 1994 Oct;14(10):followi.
PMID: 8046466 [PubMed - indexed for MEDLINE]

36: Lou X, Bixby JL.
Abstract Coordinate and noncoordinate regulation of synaptic vesicle protein genes during embryonic development.
Dev Biol. 1993 Sep;159(1):327-37.
PMID: 8365570 [PubMed - indexed for MEDLINE]

37: Bixby JL, Jhabvala P.
Abstract Tyrosine phosphorylation in early embryonic growth cones.
J Neurosci. 1993 Aug;13(8):3421-32.
PMID: 7688039 [PubMed - indexed for MEDLINE]

38: Bixby JL, Jhabvala P.
Abstract Inhibition of tyrosine phosphorylation potentiates substrate-induced neurite growth.
J Neurobiol. 1992 Jul;23(5):468-80.
PMID: 1279111 [PubMed - indexed for MEDLINE]

39: Bixby JL.
Abstract Identification of an alternatively spliced avian member of the synaptophysin gene family.
Brain Res Mol Brain Res. 1992 May;13(4):339-48.
PMID: 1320722 [PubMed - indexed for MEDLINE]

40: Bixby JL.
Abstract Diversity of axonal growth-promoting receptors and regulation of their function.
Curr Opin Neurobiol. 1992 Feb;2(1):66-9. Review.
PMID: 1322208 [PubMed - indexed for MEDLINE]

41: Bixby JL, Harris WA.
No abstract Molecular mechanisms of axon growth and guidance.
Annu Rev Cell Biol. 1991;7:117-59. Review. No abstract available.
PMID: 1687312 [PubMed - indexed for MEDLINE]

42: Bixby JL, Jhabvala P.
Free Full Text Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.
J Cell Biol. 1990 Dec;111(6 Pt 1):2725-32.
PMID: 2277083 [PubMed - indexed for MEDLINE]

43: Bixby JL, Zhang R.
Free Full Text Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.
J Cell Biol. 1990 Apr;110(4):1253-60.
PMID: 2324197 [PubMed - indexed for MEDLINE]

44: Bixby JL.
Abstract Protein kinase C is involved in laminin stimulation of neurite outgrowth.
Neuron. 1989 Sep;3(3):287-97.
PMID: 2561968 [PubMed - indexed for MEDLINE]

45: Reichardt LF, Bixby JL, Hall DE, Ignatius MJ, Neugebauer KM, Tomaselli KJ.
No abstract Integrins and cell adhesion molecules: neuronal receptors that regulate axon growth on extracellular matrices and cell surfaces.
Dev Neurosci. 1989;11(4-5):332-47. Review. No abstract available.
PMID: 2551626 [PubMed - indexed for MEDLINE]

46: Bixby JL, Lilien J, Reichardt LF.
Free Full Text Identification of the major proteins that promote neuronal process outgrowth on Schwann cells in vitro.
J Cell Biol. 1988 Jul;107(1):353-61.
PMID: 3392103 [PubMed - indexed for MEDLINE]

47: Tomaselli KJ, Neugebauer KM, Bixby JL, Lilien J, Reichardt LF.
Abstract N-cadherin and integrins: two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces.
Neuron. 1988 Mar;1(1):33-43.
PMID: 2856086 [PubMed - indexed for MEDLINE]

48: Bixby JL, Pratt RS, Lilien J, Reichardt LF.
Free in PMC Neurite outgrowth on muscle cell surfaces involves extracellular matrix receptors as well as Ca2+-dependent and -independent cell adhesion molecules.
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2555-9.
PMID: 3031688 [PubMed - indexed for MEDLINE]

49: Bixby JL, Reichardt LF.
Abstract Effects of antibodies to neural cell adhesion molecule (N-CAM) on the differentiation of neuromuscular contacts between ciliary ganglion neurons and myotubes in vitro.
Dev Biol. 1987 Feb;119(2):363-72.
PMID: 3803709 [PubMed - indexed for MEDLINE]

50: Tomaselli KJ, Reichardt LF, Bixby JL.
Free Full Text Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices.
J Cell Biol. 1986 Dec;103(6 Pt 2):2659-72.
PMID: 3025222 [PubMed - indexed for MEDLINE]

51: Van Essen DC, Newsome WT, Maunsell JH, Bixby JL.
Abstract The projections from striate cortex (V1) to areas V2 and V3 in the macaque monkey: asymmetries, areal boundaries, and patchy connections.
J Comp Neurol. 1986 Feb 22;244(4):451-80.
PMID: 3958238 [PubMed - indexed for MEDLINE]

52: Bixby JL, Reichardt LF.
Abstract The expression and localization of synaptic vesicle antigens at neuromuscular junctions in vitro.
J Neurosci. 1985 Nov;5(11):3070-80.
PMID: 3932606 [PubMed - indexed for MEDLINE]

53: Bixby JL, Spitzer NC.
Abstract Early differentiation of vertebrate spinal neurons in the absence of voltage-dependent Ca2+ and Na+ influx.
Dev Biol. 1984 Nov;106(1):89-96.
PMID: 6092180 [PubMed - indexed for MEDLINE]

54: Bixby JL, Spitzer NC.
Abstract The appearance and development of neurotransmitter sensitivity in Xenopus embryonic spinal neurones in vitro.
J Physiol. 1984 Aug;353:143-55.
PMID: 6148408 [PubMed - indexed for MEDLINE]

55: Bixby JL, Spitzer NC.
Abstract Enkephalin reduces calcium action potentials in Rohon-Beard neurons in vivo.
J Neurosci. 1983 May;3(5):1014-8.
PMID: 6842279 [PubMed - indexed for MEDLINE]

56: Bixby JL, Spitzer NC.
Abstract Enkephalin reduces quantal content at the frog neuromuscular junction.
Nature. 1983 Feb 3;301(5899):431-2.
PMID: 6823319 [PubMed - indexed for MEDLINE]

57: Bixby JL, Spitzer NC.
No abstract The appearance and development of chemosensitivity in Rohon-Beard neurones of the Xenopus spinal cord.
J Physiol. 1982 Sep;330:513-36. No abstract available.
PMID: 6294289 [PubMed - indexed for MEDLINE]

58: Van Essen DC, Newsome WT, Bixby JL.
Abstract The pattern of interhemispheric connections and its relationship to extrastriate visual areas in the macaque monkey.
J Neurosci. 1982 Mar;2(3):265-83.
PMID: 7062108 [PubMed - indexed for MEDLINE]

59: Van Essen DC, Maunsell JH, Bixby JL.
Abstract The middle temporal visual area in the macaque: myeloarchitecture, connections, functional properties and topographic organization.
J Comp Neurol. 1981 Jul 1;199(3):293-326.
PMID: 7263951 [PubMed - indexed for MEDLINE]

60: Bixby JL.
Abstract Ultrastructural observations on synapse elimination in neonatal rabbit skeletal muscle.
J Neurocytol. 1981 Feb;10(1):81-100.
PMID: 7310447 [PubMed - indexed for MEDLINE]

61: Bixby JL, Maunsell JH, Van Essen DC.
No abstract Effects of motor unit size on innervation patterns in neonatal mammals.
Exp Neurol. 1980 Dec;70(3):516-24. No abstract available.
PMID: 6160045 [PubMed - indexed for MEDLINE]

62: Bixby JL, Van Essen DC.
Abstract Competition between foreign and original nerves in adult mammalian skeletal muscle.
Nature. 1979 Dec 13;282(5740):726-8.
PMID: 514353 [PubMed - indexed for MEDLINE]

63: Bixby JL, van Essen DC.
Abstract Regional differences in the timing of synapse elimination in skeletal muscles of the neonatal rabbit.
Brain Res. 1979 Jun 22;169(2):275-86.
PMID: 445158 [PubMed - indexed for MEDLINE]

64: Woolf NK, Bixby JL, Capranica RR.
Abstract Prenatal experience and avian development: brief auditory stimulation accelerates the hatching of Japanese quail.
Science. 1976 Nov 26;194(4268):959-60.
PMID: 982054 [PubMed - indexed for MEDLINE]


1985 Fellowship
University of California, San Francisco
1983 Postdoctoral Fellow
University of California, San Diego
1980 PhD
California Institute of Technology
1975 AB
Cornell University