Richard L. Rotundo, Ph.D.
General Information
Contact
- Fax: 305-243-5885
- .(JavaScript must be enabled to view this email address)
Languages
- English
- English, Portuguese, French
Roles
- Professor of Cell Biology
CV
Research Interests
Our research focuses on the biogenesis, folding, and trafficking of acetylcholinesterase, the enzyme that terminates cholinergic neurotransmission in the central and peripheral nervous systems.
Education
1980 Postdoctoral Fellowship
Carnegie Institution of Washington, Department of Embryology
1976 PhD
University of Connecticut
1971 BS
Purdue University
Publications
- Translational Regulation of Acetylcholinesterase by the RNA-Binding Protein PUM2 at the Neuromuscular Synapse
- Rate Limiting Role of Protein Disulfide Isomerase in the Assembly and Expression of Synaptic Acetylcholinesterase in Muscle
- Absence of Acetylcholinesterase at the Neuromuscular Junctions of Perlecan-null Mice
- Rotundo publications
Biography
Dr. Rotundo is a cell biologist whose research focuses on acetylcholinesterase (AChE), an important component of the neuromuscular junction and all cholinergic synapses in the central and peripheral nervous systems. After receiving his doctoral degree Dr. Rotundo changed fields to study the development of the neuromuscular junction at the Carnegie Institution of Washington, Department of Embryology, in the laboratory of Douglas Fambrough. Three years later he became Associate Staff Member at the institution and began studying the biogenesis and regulation of AChE in muscles and nerves. Over the past forty years his work on AChE has been published in Cell, Nature Neuroscience, Neuron, PNAS, the Journal of Biological Chemistry and the Journal of Cell Biology. Dr. Rotundo has served as a member of several NIH Study Sections and other review boards, and has served on the editorial boards of the Journal of Cell Biology and the Journal of Biological Chemistry.