UHealth - University of Miami Health System

Niramol Savaraj, M.D.

General Information

Niramol  Savaraj, M.D.


  • .(JavaScript must be enabled to view this email address)


  • English


  • Research Professor


Clinical Interests

Lung cancer research in ER stress and brain  tumor and drug resistance in melanoma.

Research Interests

Cisplatin resistant, mTOR signaling and nutritional deprivation.  New target for brain tumor treatment.


Mahidol University
St. Vincent's Medical Center
Jackson Memorial Hospital, University of Miami - Affiliated Medical Education Program


  • Wangpaichitr M, Wu CJ, Bigford G, Theodoropoulos G, You M, Li YY, Verona-Santos j, Feun LG, Nguyen DM, Savaraj N.Combination of arginine deprivation with TRAIL treatment as a targeted therapy for mesothelioma. Anticancer Research. 2014 (In press)
  • Savaraj N, Wu CJ, Li YY, Wangpaichitr M, You M, Bomalaski JS, He W, Kuo MT, Feun LG. Targeting Argininosuccinate Synthetase Negative Melanomas Using Combination of Arginine Degrading Enzyme and Cisplatin, Mol Cancer Ther. 2014 (Accepted with Minor Revision)
  • Matsangou M, Santos ES, RaezL, Gomwz JE, Dinh V, and Savaraj N. Early stage non-small cell lung cancer , role of adjuvant chemotherapy and promising modalities to improve prognosis and survival outcome Future Medicine 3(1) 1-15 2014.
  • Liang ZD, Long Y, Chen HH, Savaraj N, Kuo MT. Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem; 2014
  • You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro. J Thorac Cardiovasc Surg, Jan;147(1):508-16; 2014.
  • Long Y, Tsai WB, Wangpaichitr M, Tsukamoto T, Savaraj N, Feun LG, Kuo MT. Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence and Glutamine Addiction, Mol Cancer Ther. 2013 Aug 29.
  • You M, Savaraj N, Kuo MT, Wangpaichitr M, Varona-Santos J, Wu C, Nguyen DM, Feun L. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem, Nov 11(1-2), 181-90; 2013.
  • Kuo MT, Fu S, Savaraj N, Chen HH. Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy. Cancer Res, Sep 15;72(18):4616-21; 2012
  • Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther, Nov(11):2483-94; 2012
  • Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, Kuo M.T. Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells. Cancer Res (Epub ahead of printing); 2012
  • Liang ZD, Tsai WB, Lee MY, Savaraj N, Kuo MT. Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression. Mol Pharmacol, 1:455-64; 2012
  • Feun LG, Marini A, Walker G, Elgart G, Moffat F, Rodgers S.E., Wu C.J., You M, Wangpaichitr M, Kuo M.T., Sisson W, Jungbluth A.A., Bomalaski J, Savaraj N. Negativeargininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase. Br J Cancer; 2012
  • Wangpaichitr M, Theodoropoulos G, Wu C, You M, Feun LG, Kuo M.T., Savaraj N. The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells. Mol Cancer Ther, 11:604-615; 2012
  • Wangpaichitr M, Theodoropoulos G, Wu C, You M, Feun LG, Kuo M.T., Savaraj N. The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells. Mol Cancer Ther, 11:604-615; 2012
  • Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Onco. Target, 2010
  • Savaraj N, You Min, Wu C.J., Wangpaichitr M, Kuo M.T., Feun L.G. Arginine deprivation, Autophagy, Apoptosis (AAA) for the treatment of Melanoma. Curr Mol Med, 10(4):405-412; 2010
  • Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, Savaraj N, Lampidis TJ. 2-Deoxy-D-glucose activates autophagy via ER stress rather than ATP depletion. Cancer Chemother Pharmacol, (Epub ahead of print), Jul-1; 2010
  • You M, Savaraj N, Wangpaichitr M, Wu C, Kuo M.T, Varona-Santos J, Nguyen D, Feun L. The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines. Biochem Biophys Res Commun, 394(3)2010:760-6
  • Wangpaichitr M, Wu C, You M, Maher JC, Feun LG, Savaraj. N. N'1,N'3-Dimethyl-N'1,N'3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS). Cancers, (1), 2009:23-28
  • Tsai W-B, Aiba I, Lee S-Y, Feun L, Savaraj N, Kuo MT. Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1a/Sp4. Mol. Cancer. Ther., 2009: 3223-33.