UHealth - University of Miami Health System

Manuel Blandino Rosano, PhD

General Information

Manuel  Blandino Rosano, PhD


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  • English
  • English
  • Spanish


  • Research Assistant Professor

Research Interests

  • Beta cell regeneration/proliferation.
  • Growth factor-mediated pancreatic Beta cell replication and signaling.

  • Islet transplantation.


2015 Research Assistant Professor
University of Miami
2014 Postdoctoral
University of Michigan
2014 Research Investigator
University of Michigan
2009 M.S
School of Medicine. University of Cdiz.
2009 PhD
School of Medicine. University of Cdiz
2004 M. Sc
School of Biology University of Seville, Spain
2003 B. Sc.
School of Biology University of Seville, Spain
2002 B. Sc.
School of Biology University of Seville, Spain


  • Natural history of ß-cell adaptation and failure in type 2 diabetes.
  • Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors.
  • Long-lived crowded litter (CL) mice exhibit lasting effects on insulin sensitivity and energy homeostasis.
  • Nitric oxide is a mediator of antiproliferative effects induced by proinflammatory cytokines on pancreatic beta cells.
  • mTORC1 signaling and regulation of pancreatic ß-cell mass.
  • Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 ( Cip ).
  • TSC1/TSC2 Signaling in Pancreatic ß-Cells.
  • Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.
  • Decrease in beta-cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: beneficial role of Exendin-4.
  • Anti-Proliferative effect of pro-inflammatory cytokines in cultured beta cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: Protective role of glucagon-like-peptide 1.