Stephen Lee
General Information
Contact
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Languages
- English
Roles
- Chair, The Scientific Advisory Board, Sylvester Comprehensive Cancer Center
- Director, The Executive PhD Program
- Leader of the Tumor Biology Program, Sylvester Comprehensive Cancer Center
- Professor of Biochemistry and Molecular Biology
Research Interests
The laboratory studies mechanisms involved in the cellular adaptation to the adverse environmental conditions commonly found within the tumor microenvironment (hypoxia and extracellular acidosis). These extracellular stimuli alter fundamental cellular pathways by
1. Activating an alternate translation apparatus that synthesizes proteins only in the absence of oxygen and
2. Inducing a new class of long noncoding RNAs that regulate protein function.
Ongoing projects blend basic and translational scientific research from the identification of novel stress-induced long noncoding RNA to discovery of drug as small molecular inhibitors for these essential tumor biology pathways.
Publications
- Ho et al. (2016) Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus. Cell rep. PMID: 26854219.
- Lachance et al. (2014) DNMT3a epigenetic program regulates the HIF-2a oxygen-sensing pathway and the cellular response to hypoxia. Proc. Natl. Acad. Sci. (USA) PMID: 24817692.
- Uniacke et al. (2012) An oxygen-regulated switch in the protein synthesis machinery. Nature. PMID: 22678294.
- Audas et al. (2012) Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA. Mol. Cell. PMID: 22284675
- Additional publications at PubMed