- Director of Research Faculty Development
The Desrosiers laboratory is principally interested in how individual viral genes contribute to viral pathogenesis. We are also investigating novel approaches toward a vaccine against HIV/AIDS.&nbsp; We principally use two different viruses for these studies, both viruses previously discovered by the Desrosiers laboratory:&nbsp; the simian immunodeficiency virus (SIV), a close monkey homolog of the human AIDS virus (HIV),&nbsp; and rhesus monkey rhadinovirus (RRV), a close monkey homolog of the human Kaposi sarcoma herpesvirus. Vaccine/prevention approaches currently under investigation include: AAV vector-mediated delivery of potent broadly-neutralizing antibodies; replication-competent, recombinant, persisting herpesviruses.
M.D. (Honorary), Friedrich-Alexander-University Erlangen-Nuremberg, Germany 2009
M.S. (Honorary), Harvard University 1991
Fellow of the American Academy of Microbiology
Distinguished Alumni Award, College of Arts and Sciences, Boston University
Distinguished Research Career Award, Ohio State University
Most Highly-Cited Researcher
Max Planck Research Award
John Boezi Memorial Alumni Award
Dorothy Hortsmann Memorial Lecture, Yale University
Melvin Hare Memorial Lecturer
Michigan State University
Ronald C. Desrosiers, PhD, served as director of a research institute at Harvard Medical School for 12 years prior to his arrival at the University of Miami Miller School of Medicine in 2013. Dr. Desrosiers serves as Director of Research Faculty Development and Professor in the Department of Pathology here at the Miller School of Medicine. Dr. Desrosiers was the leader of the team that discovered the simian immunodeficiency virus in 1984 and was senior author of its publication in Science in 1985. Since that time, he has made numerous seminal contributions using the SIV/macaque model to better understand the mechanisms by which HIV-1 and SIV cause disease and for vaccine development efforts. In 1990, he described the first-ever infectious, pathogenic molecular clone of this group of viruses and to this day it remains the clone of choice for controlled experiments in monkeys. Its 10,279 base-pair sequence can be manipulated in any way such that the effects on viral tropism, replicative capacity, immune avoidance, and disease propensity can be examined. Dr. Desrosiers has used this system to better understand the relative importance and functional contribution of the so-called nonessential genes and to better understand the evolution of antigenic escape variants. He has shown that live attenuated SIV deletion mutants can serve effectively as vaccines. To this day, live attenuated SIV remains the gold standard for vaccine protection against SIV in monkeys to which all other vaccine approaches are compared. This work provides hope that a vaccine against HIV will be possible. While he has previously tried a number of novel vaccine concepts using the SIV/macaque model, he is currently focused on two approaches: use of AAV vector to deliver antibodies with potent, broad neutralizing activity and the use of recombinant persistent herpesviruses as vaccine vectors. He is the discoverer of the KSHV-related gamma-2 herpesvirus of rhesus monkeys called rhesus monkey rhadinovirus that is being used for the latter efforts. He has been a strong advocate for basic and discovery research in the world’s AIDS vaccine efforts.