• Exosome-mediated inflammasome signaling after central nervous system injury. de Rivero Vaccari JP, Brand F 3rd, Adamczak S, Lee SW, Barcena JP, Wang MY, Bullock MR, Dietrich WD, Keane RW. Pattern recognition receptors and central nervous system repair. Kigerl KA, de Rivero Vaccari JP, Dietrich WD, Popovich PG, Keane RW. Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. Adamczak SE, de Rivero Vaccari JP, Dale G, Brand FJ 3rd, Nonner D, Bullock MR, Dahl GP, Dietrich WD, Keane RW.
• de Rivero Vaccari JP, Dietrich WD, Keane RW (2016) Therapeutics targeting the inflammasome after central nervous system injury. Transl. Res. Jan;167(1):35-45. doi: 10.1016/j.trsl.2015.05.003 Epub 2015 May 12. de Rivero Vaccari, JP, Brand III, F, Adamczak, S, Lee, SW, Perez Barcena, J, Wang, MY, Bullock, MR, Dietrich, WD, Keane, RW (2015) Exosome-mediated inflammasome signaling after central nervous system injury. J. Neurochem. J Neurochem. 2015 Jan 27. doi: 10.1111/jnc.13036. de Rivero Vacc

Regulation of Innate Immunity after CNS Trauma

Innate immunity is the first line of defense against pathogens and host-derived signals of cellular stress.  My research focuses on investigating mechanisms that direct normal innate immunity and its dysregulation in central nervous system injury and disease, including (1) agonists and activation mechanisms of inflammasomes, (2) regulatory mechanisms that potentiate or limit inflammasome activation after injury, and (3) emerging links between innate immunity and Alzheimer’s disease.