Research interests are in three areas:

The mechanisms controlling the selectivity and conductance of ion channels.

The mechanisms controlling how ion channels gate their pores.

The mechanisms involved in short term synaptic plasticity.

 

• Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels. J. Gen Physiol. 2017, 149:373-387
• A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities. J Biol Chem. 2017 pii: jbc.M117.776013. doi: 10.1074/jbc.M117.776013
• Single-channel kinetics of BK (Slo1) channels. Front Physiol. 2015 Jan 21;5:532. doi: 10.3389/fphys.2014.00532. eCollection 2014.
• Exponential sum-fitting of dwell-time distributions without specifying starting parameters. Biophys J. 2013, 104:2383-91
• Properties of Slo1 K+ channels with and without the gating ring. Proc Natl Acad Sci U S A. 2013, 110:16657-62.
• COMPLETE BIBLIOGRAPHY

1971-1975  Assistant Professor, Department of Physiology and Biophysics, Univ. Miami Miller School Medicine

1975-1980  Associate Professor, Department of Physiology and Biophysics, Univ. Miami Miller School Medicine

1980-          Professor, Department of Physiology and Biophysics, Univ. Miami Miller School of Medicine 

1992-          Chairman, Department of Physiology and Biophysics, Univ. Miami Miller School of Medicine