Fangliang Zhang
General Information

Contact
- .(JavaScript must be enabled to view this email address)
Languages
- English
Roles
- Asst. Professor
CV
Research Interests
Education
B.S.
University of Science & Technology of China, Hefei
PhD
University of Florida
Postdoctoral training
University of Pennsylvania
Publications
- Zhang F, Saha S, Kashina A. Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion. J Cell Biol 2012 Jun 11;197(6):819-36.
- Zhang F, Saha S, Shabalina S, Kashina A. Differential arginylation of actin isoforms is regulated by coding-sequence-dependent degradation. Science 2010, Sep 17;329(5998):1534
- Zhang F *, Patel D*, Colavita K, Rodionova I, Buckley B, Scott D, Kumar A, Shabalina SA, Saha S, Chernov M, Osterman A, Kashina A. (*Equal contribution) Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophospate synthase. Nat Commun. 2015 Jul 15;6:7517. doi: 10.1038/ncomms8517. PMID: 26175007
- Rai R*, Zhang F*, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Gyorffy B, Dong DW, Shtutman M, Kashina A. (* Equal contribution) Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. . Oncogene. 2016 Aug 4;35(31):4058-68. doi: 10.1038/onc.2015.473. Epub 2015 Dec 2
- Kumar A, Birnbaum MD, Patel DM, Morgan WM, Singh J, Barrientos A, Zhang F. Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response. Cell Death and Disease (2016) 7, e2378; doi:10.1038/cddis.2016.284
- Link for additional publications on my Pubmed profile
Biography
Through my training and research experience, I have developed a multi-disciplinary expertise. I was trained as a biochemist by an enzymologist Dr. Daniel Purich at the University of Florida. In my first postdoctoral position, I was trained by Dr. John Murray at the University of Pennsylvania to learn cutting-edge skills in electron microscopy and optical imaging. In my second postdoctoral experience I was working with Dr. Anna Kashina at the University of Pennsylvania to use both my skills in biochemistry and cell biology in studying posttranslational arginylation. My own laboratory’s major focus is the effects of posttranslational modifications ((including arginylation, acetylation, ubiquitination, and proteolysis) on cellular behaviors such as cell adhesion/migration, stress response and programmed cell death. Particularly, our lab is one of the very few places in the world (probably less than 10) that have demonstrated expertise in studying arginylation. Our research topic is a multidisciplinary topic at the interface between biochemistry, cell biology and developmental biology. We are particularly interested in elucidating the role of posttranslational arginylation in regulating cell contact inhibition in the culture, and progression of prostate cancers in human patients. Our lab is funded by a R01 from NIH/NIGMS, and several other grants from DoD/CDMRP, the Sylvester Cancer Center and other resources.